Dr Varadarajan has made outstanding contribution in the area of protein folding. He has incisively explored the relationship between protein sequence, three-dimensional structure and thermodynamic stability. His work has led to the development of new methods for depth probing in protein structure and for predicting temperature sensitive mutants from sequences. His work has provided experimental tests of sequence-stability relationships. His work has also provided new insights into the forces driving fragment complementation and the nature of disordered states in proteins.