Dr Sasisekharan has done significant work on the conformation of biopolymers, specially polynucleotides and polypeptides. He has developed incisive methods for arriving at optimal conformations of macromolecules. These methods have led him to suggest an alternative model for the Watson-Crick double helical structure of DNA. This model permits separation of polynucleotides without uncoiling and provides a novel solution to an unsolved paradox in biology.