Dr Krishnamurthy has made fundamental contribution to the design of error-free arithmetic unit using p-adic numbers. The computer science research group headed by Prof. Krishnamurthy has developed new algebraic techniques for the reconstruction of three-dimensional objects using two-dimensional projections at different angles. He has developed a new computer language for storing and retrieving chemical information. Prof. Krishnamurthy has made significant contributions to the design of algorithms for computer vision, pattern and shape analysis. He has developed an algorithm for automatic phonetic transcription of Tamil in Roman script.